Hamman RF, Bell RA, Dabelea D, DAgostino RB, Dolan L, Imperatore G et al (2014) The

SEARCH for diabetes in youth study: rationale,ndings, and future directions. Diabetes Care

37(12):33363344

Hong S, Morrow TJ, Paulson PE, Isom LL, Wiley JW (2004) Early painful diabetic neuropathy is

associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in

dorsal root ganglion neurons in the rat. J Biol Chem 279:2934129350

International Diabetes Foundation (2019) International Diabetes Federationfacts &gures

Jaiswal M, Divers J, Dabelea D, Isom S, Bell RA, Martin CL et al (2017) Prevalence of and risk

factors for diabetic peripheral neuropathy in youth with type 1 and type 2 diabetes: search for

diabetes in youth study. Diabetes Care 40(9):12261232

Javed S, Petropoulos IN, Alam U, Malik RA (2015) Treatment of painful diabetic neuropathy. Ther

Adv Chronic Dis 6(1):1528

Joseph EK, Levine JD (2004) Caspase signalling in neuropathic and inammatory pain in the rat.

Eur J Neurosci 20(11):28962902

Kishi M, Tanabe J, Schmelzer JD, Low PA (2002) Morphometry of dorsal root ganglion in chronic

experimental diabetic neuropathy. Diabetes 51(3):819824

Kukkar A, Bali A, Singh N, Jaggi AS (2013) Implications and mechanism of action of gabapentin in

neuropathic pain. Arch Pharm Res 36(3):237251

Kurreck J (2006) siRNA efciency: structure or sequencethat is the question. J Biomed

Biotechnol 2006:83757

Liang S, Xu C, Li G, Gao Y (2010) P2X receptors and modulation of pain transmission: focus on

effects of drugs and compounds used in traditional Chinese medicine. Neurochem Int 57(7):

705712

Lindsay TJ, Rodgers BC, Savath V, Hettinger K (2010) Treating diabetic peripheral neuropathic

pain. Am Fam Physician 82(2):151158

Lipp P, Reither G (2011) Protein kinase C: themasters of calcium and lipid. Cold Spring Harb

Perspect Biol 3:a004556

Liu C, Tao J, Wu H, Yang Y, Chen Q, Deng Z et al (2017) Effects of LncRNA BC168687 siRNA

on diabetic neuropathic pain mediated by P2X7 receptor on SGCs in DRG of rats. Biomed Res

Int 2017:7831251

Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI et al (2002) Injury type-

specic calcium channel α2δ-1 subunit up-regulation in rat neuropathic pain models correlates

with antiallodynic effects of gabapentin. J Pharmacol Exp Ther 303(3):11991205

Mamet J, Baron A, Lazdunski M, Voilley N (2002) Proinammatory mediators, stimulators of

sensory neuron excitability via the expression of acid-sensing ion channels. J Neurosci 22(24):

1066210670

Martin CL, Albers JW, Pop-Busui R (2014) Neuropathy and relatedndings in the diabetes control

and complications trial/epidemiology of diabetes interventions and complications study. Diabe-

tes Care 37(1):3138

Maser RE, Steenkiste AR, Dorman JS, Nielsen VK, Bass EB, Manjoo Q et al (1989) Epidemiologi-

cal correlates of diabetic neuropathy. Report from Pittsburgh epidemiology of diabetes

complications study. Diabetes 38(11):14561461

McCarthy BG, Hsieh ST, Stocks A, Hauer P, Macko C, Cornblath DR et al (1995) Cutaneous

innervation in sensory neuropathies: evaluation by skin biopsy. Neurology 45(10):18481855

McClelland D, Evans RM, Barkworth L, Martin DJ, Scott RH (2004) A study comparing the

actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG

neurones from neonatal rats. BMC Pharmacol 4:14

Meng QS, Yin Q, Li YP (2013) Nanocarriers for siRNA delivery to overcome cancer multidrug

resistance. Chin Sci Bull 58:40214030

Misawa S, Sakurai K, Shibuya K, Isose S, Kanai K, Ogino J et al (2009) Neuropathic pain is

associated with increased nodal persistent Na+ currents in human diabetic neuropathy. J

Peripher Nerv Syst 14(4):279284

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siRNA-Encapsulated Nanoparticles for Targeting Dorsal Root Ganglion (DRG). . .

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